HIGHLY EFFICIENT CLINICAL TRIALS SIMULATOR (HECT): SOFTWARE APPLICATION FOR PLANNING AND SIMULATING PLATFORM ADAPTIVE TRIALS [VERSION 2; PEER REVIEW: 1 APPROVED, 2 APPROVED WITH RESERVATIONS]

Background: Adaptive designs and platform designs are among two common clinical trial innovations that are increasingly being used to manage medical intervention portfolios and attain faster regulatory approvals.Planning of adaptive and platform trials necessitate simulations to understand how a set of adaptation rules will likely affect the proper

In this study, we developed a novel, multiplex qPCR assay for simultaneous detection of RIG-1, MDA5, and IFIT-1 at the mRNA level.The assay was validated in A549 cells transfected with in vitro transcribed RNAs.Both exogenous te01-4147c RNA-GFP and self-amplifying (saRNA-GFP) induced significant expression of RIG-1, MDA5, IFIT-1, as well as type I

In this study, we developed a novel, multiplex qPCR assay for simultaneous detection of RIG-1, MDA5, and IFIT-1 at the mRNA level.The assay was validated in A549 cells transfected with in vitro transcribed RNAs.Both exogenous te01-4147c RNA-GFP and self-amplifying (saRNA-GFP) induced significant expression of RIG-1, MDA5, IFIT-1, as well as type I

Flight schedules are highly sensitive to delays and witness these events on a very frequent basis.In an interconnected and interdependent air transportation system, these delays can magnify and cascade alesis vi61 as the flight itineraries progress, causing reactionary delays.The airlines, passengers and airports bear the negative economic implicat